Sulfuric Acid → 4-(Chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole

Participants

Reaction Conditions

Reaction Steps

408 mg (3.21 mmol) of 1,3-dichloroacetone and 500 mg (3.21 mmol) of 4-chlorobenzamide are combined and stirred at 135° C. for 1 h. The mixture is then cooled to RT, 1.1 ml of conc. sulfuric acid are added carefully and the mixture is stirred for 5 min. The mixture is carefully poured onto ice. The precipitate is filtered off with suction and washed with water. After drying the crude product is used in the next reaction without further purification.

Provenance & Evidence