反应详情

2.00 g (12.80 mmol) of 4-fluoro-3-methylbenzamide and 1.79 g (14.08 mmol) of 1,3-dichloroacetone are stirred at 130° C. for 2 days, resulting in the formation of a melt. The mixture is then cooled to RT, 3.0 ml of conc. sulfuric acid are added carefully at this temperature and the mixture is stirred for 15 min. The suspension obtained is poured into 20 ml of ice-water and stirred at RT overnight. The precipitate formed is filtered off and dried in a vacuum drying cabinet at 40° C. overnight.

1. customresulting in the formation of a melt
2. customThe suspension obtained
3. stirringstirred at RT overnight
4. customThe precipitate formed
5. filtrationis filtered off
6. customdried in a vacuum
7. customdrying cabinet at 40° C. overnight