Sodium Bicarbonate → HCID 24958699, compound

Participants

Reaction Steps

60 mg (0.16 mmol) of the compound from Example 29A are dissolved in 3 ml of dry DMF, and 46 mg (0.19 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 53 mg (0.63 mmol) of sodium bicarbonate are added in succession. The reaction mixture is stirred at RT for 8 h. After removal of the solvent on a rotary evaporator the residue is directly purified by preparative HPLC (column: YMC GEL ODS-AQ S-5, 15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).

Provenance & Evidence