Lithium Hydroxide → HCID 24958702, compound

Participants

Reaction Steps

65 mg (0.12 mmol) of the compound from Example 10 are initially charged in a mixture of 3.5 ml of dioxane and 1.7 ml of water, and 11 mg of lithium hydroxide are added. The mixture is initially stirred at RT for 8 h. Another 22 mg of lithium hydroxide are then added, and the mixture is stirred at RT for a further 16 h. The solvent is then removed on a rotary evaporator. The residue is taken up in 10 ml ethyl acetate and washed once with 3 ml of saturated aqueous sodium bicarbonate solution. The mixture is dried over magnesium sulfate. After removal of the solvent on a rotary evaporator the residue is purified chromatographically on silica gel 60 (mobile phase: gradient dichloromethane/ethanol 50:1→10:1).

Provenance & Evidence