Sodium Bicarbonate → Rac-2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-(tetrahydro-2h-pyran-2-yl)-pyridine-3,5-dicarbonitrile

Beteiligte Stoffe

Reaktionsschritte

33 mg (0.10 mmol) of the compound from Example 31A, 29 mg (0.12 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 33 mg (0.39 mmol) of sodium bicarbonate are suspended in 2 ml of dry DMF. The reaction mixture is stirred at RT for 20 h. The mixture is filtered and directly purified by preparative HPLC (column: YMC GEL ODS-AQ S-5, 15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).

Herkunft & Nachweise