Sodium Bicarbonate → HCID 24959788, compound

Participants

Reaction Steps

50 mg (0.13 mmol) of the compound from Example 32A, 39 mg (0.16 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 45 mg (0.54 mmol) of sodium bicarbonate are initially charged in 3 ml of dry DMF. The reaction mixture is stirred at RT for 12 h and then directly purified by preparative HPLC (column: YMC GEL ODS-AQ S-5, 15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).

Provenance & Evidence