HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-6-methyl-4-(tetrahydro-2H-pyran-2-yl)-pyridine-3,5-dicarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-(Chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole | HCID 610297 | — |
| Reactant | Rac-2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-(tetrahydro-2h-pyran-2-yl)-pyridine-3,5-dicarbonitrile | HCID 24959059 | — |
| Reactant | HCID 178433544 | HCID 178433544 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-6-methyl-4-(tetrahydro-2H-pyran-2-yl)-pyridine-3,5-dicarbonitrile | HCID 68697435 | — |
Reaction Steps
50 mg (0.14 mmol) of the compound from Example 41A, 40 mg (0.16 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 45 mg (0.54 mmol) of sodium bicarbonate are reacted in 2.8 ml of dry DMF analogously to the preparation of the compound of Example 14.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304412B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-876749ec4581450ebcc6c43513a92540 |
| Source note | uspto-grants-2012_11 |