HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloromethylthiazol-2-ylamine → rac-2-Amino-6-{[(2-amino-1,3-thiazol-4-yl)methyl]sulfanyl}-4-(tetrahydro-2H-pyran-2-yl)-pyridine-3,5-dicarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloromethylthiazol-2-ylamine | HCID 73229 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Rac-2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-(tetrahydro-2h-pyran-2-yl)-pyridine-3,5-dicarbonitrile | HCID 24959059 | — |
| Reactant | HCID 178510477 | HCID 178510477 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | rac-2-Amino-6-{[(2-amino-1,3-thiazol-4-yl)methyl]sulfanyl}-4-(tetrahydro-2H-pyran-2-yl)-pyridine-3,5-dicarbonitrile | HCID 87548657 | — |
Reaction Steps
50 mg (0.14 mmol) of the compound from Example 31A, 39 mg (0.21 mmol) of 4-(chloromethyl)-1,3-thiazol-2-amine and 48 mg (0.58 mmol) of sodium bicarbonate in 2.0 ml of dry DMF are reacted analogously to the preparation of the compound of Example 14.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304412B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-443d51d92dc846279f633e268e4993b8 |
| Source note | uspto-grants-2012_11 |