Sodium Hydroxide → HCID 67373773, compound

HRID 1873641Notes

Reaction equation

HRID 1873641 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([Cl:14])=[CH:9][N:8]=2)[N:5]=[C:4]([CH:15]([CH3:17])[CH3:16])[C:3]=1[C:18]#[N:19].[OH-:20].[Na+]>OS(O)(=O)=O>[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([Cl:14])=[CH:9][N:8]=2)[N:5]=[C:4]([CH:15]([CH3:17])[CH3:16])[C:3]=1[C:18]([NH2:19])=[O:20]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67369848HCID 67369848, compound

Product 1

HCID 67373773HCID 67373773, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

5-Amino-1-(3,5-dichloropyridyl)-3-isopropyl-1H-pyrazole-4-carbonitrile (56 g, 189 mmole) was taken up in concentrated H2SO4 (160 mL) and stirred at room temp for 16 hours. The reaction was then poured onto 3M aqueous NaOH (2 L) at 0° C. The resulting solid was then filtered and washed with H2O (1 L). The product was then dried under vacuum to yield the desired amide (49 g, 82% yield).

Workup

  1. filtrationThe resulting solid was then filtered
  2. washwashed with H2O (1 L)
  3. customThe product was then dried under vacuum

Sources & evidence

ORD record
ord-b03fccd6f38d4f649447b697463e9513
Source dataset
uspto-grants-2012_11
Patent number
US08304418B2

Reaction notes

Loading…