Hydrochloric Acid → HCID 68424025, compound

Participants

Reaction Steps

To a solution of [2-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (1.35 g, 4.30 mmol) in DCM (50 mL) was added HCl (4 M in dioxane, 11 mL, 44 mmol) at room temperature. The reaction mixture was stirred for 2 hours at room temperature. The precipitate formed was filtered through a filter paper, washed with DCM and dried under vacuum to give 2-amino-1-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-ethanone HCl salt (1.06 g, 99%) as a white solid. 1H NMR (400 MHz, CDCl3) δ: 8.50 (s, 1H), 8.42 (brs, 3H), 7.88 (d, J=8.0 Hz, 1H), 7.20 (m, 1H), 7.03 (d, J=8.0 Hz, 1H), 4.28 (m, 4H), 2.95 (t, J=5.6 Hz, 2H), 2.15 (m, 2H). LCMS: m/e 215.21 [M+H].

Provenance & Evidence