HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-nitrophenol → HCID 86650695, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-nitrophenol | HCID 9825 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,1-Dimethylethyl 4-chloro-7-methoxy-6-quinolinecarboxylate | HCID 86650696 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 86650695 | HCID 86650695 | 93% |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
Compound 1a (3.60 g) was dissolved in N-methylpyrrolidin-2-one (14 mL), and diisopropylethylamine (6.55 mL) and 2-fluoro-4-nitrophenol (2.89 g) were added to the solution. The mixture was heated to 140° C. and stirred for 4 hours. To the reaction mixture, distilled water was added on an ice bath, and the precipitate was filtrated, to thereby yield compound 1b (4.71 g, yield: 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304427B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-4b5b741336a4406bbb24d54a24b5d587 |
| Source note | uspto-grants-2012_11 |