1,4-Dioxane hydrochloride → HCID 86650704, compound

HRID 1873691Notes

Reaction equation

HRID 1873691 reaction equation
[F:1][C:2]1[CH:27]=[C:26]([NH:28][C:29]([NH:31][C:32](=[O:41])[CH2:33][C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=2)=[S:30])[CH:25]=[CH:24][C:3]=1[O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:22][CH3:23])=[C:12]([C:15]([O:17]C(C)(C)C)=[O:16])[CH:13]=2)[N:8]=[CH:7][CH:6]=1.[ClH:42].O1CCOCC1>>[ClH:42].[F:1][C:2]1[CH:27]=[C:26]([NH:28][C:29]([NH:31][C:32](=[O:41])[CH2:33][C:34]2[CH:35]=[CH:36][C:37]([F:40])=[CH:38][CH:39]=2)=[S:30])[CH:25]=[CH:24][C:3]=1[O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:22][CH3:23])=[C:12]([C:15]([OH:17])=[O:16])[CH:13]=2)[N:8]=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86650706HCID 86650706, compound

Product 1

HCID 86650704HCID 86650704, compoundYield 66%

Conditions

Temperature
80 °C

Procedure

Compound 19a (385 mg) was dissolved in 4N HCl-dioxane solution (10 mL), and the solution was stirred at 80° C. for 4 hours. The precipitate in the reaction mixture was filtrated, to thereby yield compound 19b (245 mg, yield: 66%).

Workup

  1. filtrationThe precipitate in the reaction mixture was filtrated

Sources & evidence

ORD record
ord-25aeada75ea54aad8f5ea52e3c28ab9d
Source dataset
uspto-grants-2012_11
Patent number
US08304427B2

Reaction notes

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