1,4-Dioxane hydrochloride → HCID 66916505, compound

HRID 1873693Notes

Reaction equation

HRID 1873693 reaction equation
[F:1][C@H:2]1[CH2:6][CH2:5][N:4]([C:7](=[O:17])[CH2:8][NH:9]C(=O)OC(C)(C)C)[CH2:3]1.[ClH:18].O1CCOCC1>>[ClH:18].[NH2:9][CH2:8][C:7]([N:4]1[CH2:5][CH2:6][C@H:2]([F:1])[CH2:3]1)=[O:17]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86650707HCID 86650707, compound

Product 1

HCID 66916505HCID 66916505, compoundYield 46%

Procedure

Compound 20a (98.1 mg) was dissolved in 4N HCl-1,4-dioxane solution, and the solution was stirred at room temperature for 4 hours, to thereby yield compound 20b (33.5 mg, yield: 46%).

Sources & evidence

ORD record
ord-ed954f28ddd44ecc8f4f52fa7a4f4a88
Source dataset
uspto-grants-2012_11
Patent number
US08304427B2

Reaction notes

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