HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86650708, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(Methylsulfonyl)ethanamine | HCID 4340561 | — |
| Reactant | 4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxyquinoline-6-carboxylic acid hydrochloride | HCID 86650698 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 86650708 | HCID 86650708 | 73.1% |
Reaction Steps
Similar to the synthesis of Example 1, compound 1e (25 mg), 2-(methylsulfonyl)ethaneamine (6 mg), triethylamine (19 μL), and DMTMM•n-hydrate (20 mg) were dissolved in ethanol (1 mL), and the solution was stirred at room temperature for 1 hour, to thereby yield the titled compound 27 (20.6 mg, yield: 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304427B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-a9ddc2025dbb4d389f10af3568247eb7 |
| Source note | uspto-grants-2012_11 |