HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylacetamide → 4-(4-(3-(2-(2,6-Difluorophenyl)acetyl)thioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | HCID 66916241 | HCID 66916241 | — |
| Reactant | tert-Butyl 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxyquinoline-6-carboxylate | HCID 86650700 | — |
| Reactant | 2,6-Difluorophenylacetyl thioisocyanate | HCID 86650718 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(4-(3-(2-(2,6-Difluorophenyl)acetyl)thioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxylic acid | HCID 86650717 | — |
Reaction Steps
Similar to the synthesis of compound 1d, from compound 39c (98 mg), 2,6-difluorophenylacetyl thioisocyanate (128 mg), and a solvent mixture of N,N-dimethylacetamide (1.5 mL), toluene (1.5 mL), and ethanol (300 μL), compound 44a was yielded as a crude product (143 mg, yield: 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304427B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-f0ca9b9350ce4742860538ffdfcac617 |
| Source note | uspto-grants-2012_11 |