HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1873700Generated: November 2, 2026
Water → 4-(4-amino-2-fluorophenoxy)-7-methoxy-N-methylquinoline-6-carboxamide
https://huagongshe.com/reaction/1873700
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-Methyl-2-piperidone | HCID 13603 | — |
| Reactant | Methyl 4-(4-amino-2-fluorophenoxy)-7-methoxyquinoline-6-carboxylate | HCID 66916282 | — |
| Product | 4-(4-amino-2-fluorophenoxy)-7-methoxy-N-methylquinoline-6-carboxamide | HCID 66916350 | 64% |
Reaction Steps
Compound 39b (100 mg) was dissolved in N-methylpiperidin-2-one (250 μL), and 40% methylaminemethanol solution (250 μL) was added thereto, followed by stirring at 40° C. for 16 hours. Subseuqntly, water was added to the reaction mixture, and the precipitate was filtrated, to thereby yield compound 46a (63.7 mg, yield: 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08304427B2 |
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| Source dataset | uspto-grants-2012_11 |
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| ORD ID | ord-37178aa6bc0d4104b2c01528782603fd |
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| Source note | uspto-grants-2012_11 |
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