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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1873701Generated: November 1, 2026

tert-Butyl 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxyquinoline-6-carboxylate → 3-Methoxyphenylacetyl isothiocyanate

https://huagongshe.com/reaction/1873701

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxyquinoline-6-carboxylateHCID 86650700—
Reactant4-(2-Fluoro-4-(3-(2-(3-methoxyphenyl)acetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamideHCID 86650719—
Product3-Methoxyphenylacetyl isothiocyanateHCID 43514641—
Product4-(4-amino-2-fluorophenoxy)-7-methoxy-N-methylquinoline-6-carboxamideHCID 66916350—

Reaction Steps

Similar to the synthesis of compound 1d, from compound 46a (50.0 mg) and 3-methoxyphenylacetyl isothiocyanate (45.5 mg), the titled compound 46 was yielded (40.1 mg, yield: 50%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08304427B2
Source datasetuspto-grants-2012_11
ORD IDord-7437a01f3377486a977dd7fe01f8e057
Source noteuspto-grants-2012_11