HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxyquinoline-6-carboxylate → 4-Trifluoromethylphenylacetyl isothiocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxyquinoline-6-carboxylate | HCID 86650700 | — |
| Reactant | 4-(2-Fluoro-4-(3-(2-(4-trifluoromethylphenyl)acetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide | HCID 86650720 | — |
| Product | 4-Trifluoromethylphenylacetyl isothiocyanate | HCID 62116121 | — |
| Product | 4-(4-amino-2-fluorophenoxy)-7-methoxy-N-methylquinoline-6-carboxamide | HCID 66916350 | — |
Reaction Steps
Similar to the synthesis of compound 1d, from compound 46a (50.0 mg) and 4-trifluoromethylphenylacetyl isothiocyanate (53.9 mg), the titled compound 47 was yielded (41.2 mg, yield: 48%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304427B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-5cbad82573c843398017ca9059943713 |
| Source note | uspto-grants-2012_11 |