HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 3-Fluoro-4-nitrophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 22936555 | HCID 22936555 | — |
| Reactant | 1,1-Dimethylethyl 4-chloro-7-methoxy-6-quinolinecarboxylate | HCID 86650696 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 3-Fluoro-4-nitrophenol | HCID 520948 | — |
| Product | Methyl 4-chloro-7-methoxyquinoline-6-carboxylate | HCID 22646520 | — |
Reaction Steps
Similar to the synthesis of compound 1a, from methyl 4-chloro-7-methoxyquinoline-6-carboxylate (300 mg), 3-fluoro-4-nitrophenol (225 mg), N,N-diisopropylethylamine (415 μL), and N-methylpyrrolidin-2-one (1.5 mL), compound 49a was yielded (112 mg, yield: 25%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304427B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-9b7284ad7d934b1eb228a400436cbba5 |
| Source note | uspto-grants-2012_11 |