HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → Methyl 4-(4-amino-3-fluorophenoxy)-7-methoxyquinoline-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 4-(4-amino-3-fluorophenoxy)-7-methoxy-N-methylquinoline-6-carboxamide | HCID 66916349 | — |
| Reactant | 4-(4-amino-2-fluorophenoxy)-7-methoxy-N-methylquinoline-6-carboxamide | HCID 66916350 | — |
| Product | Methyl 4-(4-amino-3-fluorophenoxy)-7-methoxyquinoline-6-carboxylate | HCID 22936312 | 62% |
Reaction Steps
Similar to the synthesis of compound 46a, from compound 49b (50.5 mg), 40% aqueous methylamine solution (500 μL), and N-methylpyrrolidin-2-one (500 μL), compound 49c was yielded (31.2 mg, yield: 62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304427B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-15c23e1653f7452492643715be2c33c8 |
| Source note | uspto-grants-2012_11 |