Hydrochloric Acid → HCID 46938190, compound

Participants

Reaction Steps

To a solution of 7 (7.5 g, 22.8 mmol) in EtOH (150 mL) was added 5N HCl in 2-PrOH (7 mL). The solution was evaporated in vacuo, then co-evaporated 2× more with EtOH. The resulting material was dissolved in EtOH (100 mL) and the resulting solution was hydrogenated overnight with Pd(OH)2 at 50 psi. The catalyst was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with acetone and a pale yellow solid was collected. The resulting solid was recrystallized from EtOH to give the title compound as an off-white solid mp 200-202° C. 1H NMR DMSO d6 consistent with previous spectra.

Provenance & Evidence