1,1'-Difluoro-2,2'-bipyridinium Bis(tetrafluoroborate) → 5-Fluoro-1,6-dimethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid
Reaction equation
CC1(C)[O:7][C:6](=[O:8])[C:5](=[C:9]([OH:15])[CH:10]=[C:11]([NH:13][CH3:14])[CH3:12])[C:4](=O)[O:3]1.[F:18][B-](F)(F)F.F[B-](F)(F)F.F[N+]1C=CC=CC=1C1C=CC=C[N+]=1F>C(#N)C>[F:18][C:10]1[C:9]([OH:15])=[C:5]([C:6]([OH:7])=[O:8])[C:4](=[O:3])[N:13]([CH3:14])[C:11]=1[CH3:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
1.0 g of 2,2-dimethyl-5-(1-hydroxy-3-methylamino-2-butenylidene)-1,3-dioxane-4,6-dione was suspended in 20 ml of acetonitrile, 806 mg of N,N′-difluoro-2,2′-bipyridinium bis(tetrafluoroborate) was added thereto, and this was stirred at room temperature for 1 hour and at 50° C. for 30 minutes. The reaction mixture was added to 100 ml of ice water and extracted with 100 ml of chloroform twice. The organic layer was dried with anhydrous magnesium sulfate and concentrated, and the residue was subjected to silica gel column chromatography (eluent:ethyl acetate) to obtain 480 mg of 5-fluoro-1,6-dimethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid represented by the formula:
Workup
- extractionextracted with 100 ml of chloroform twice
- dry with materialThe organic layer was dried with anhydrous magnesium sulfate
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-af11095f0c5f4ae0a146bc2569e0aad6
- Source dataset
- uspto-grants-2012_11
- Patent number
- US08304437B2
Reaction notes
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