Hydrochloric Acid → HCID 53401839, compound

Participants

Reaction Steps

10 g (53.8 mmol) of 6-bromo-pyridine-2-carbaldehyde were dissolved in 70 ml of pyridine and 6.73 g (64.5 mmol) of malonic acid and 457 mg (5.4 mmol) of piperidine were added. The reaction mixture was boiled under reflux for 6 h. The solution was cooled to room temperature and then poured onto ice. Concentrated hydrochloric acid was added until pH=5, whereupon the product precipitated. The product was isolated by filtration and dried under reduced pressure. Yield: 9.85 g.

Provenance & Evidence