反应详情

5 g (23.04 mmol) of 4-fluorophenacyl bromide and 3.76 g (23.04 mmol) of 2,2-diethoxythioacetamide in 100 ml of ethanol were stirred at room temperature for 2 h. After concentration, the residue was treated with ethyl acetate and filtered. The filtrate was concentrated and the obtained residue, which consisted of the diethyl acetal of 4-(4-fluoro-phenyl)-thiazole-2-carbaldehyde, was treated with 100 ml of acetone/water and 1 ml of 2 N hydrochloric acid. After stirring at room temperature for 2 h, the reaction mixture was evaporated. Yield: 4.22 g.

1. concentrationAfter concentration
2. additionthe residue was treated with ethyl acetate
3. filtrationfiltered
4. concentrationThe filtrate was concentrated
5. additionwas treated with 100 ml of acetone/water and 1 ml of 2 N hydrochloric acid
6. customthe reaction mixture was evaporated