3-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-acrylic Acid Tert-butyl Ester → 3-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-acrylic Acid

Participants

Reaction Steps

The crude product obtained in step (b) was stirred with 10 ml of 90% trifluoroacetic acid at room temperature for 1 h. After concentration, the residue was dissolved in a dilute sodium hydroxide solution and extracted with ethyl acetate. The aqueous phase was acidified with hydrochloric acid, and the precipitated product was filtered off with suction and dried. Yield: 1.52 g.

Provenance & Evidence