反应详情

2 g (11.45 mmol) of 4-fluorobenzamidine hydrochloride, 4.09 g (11.45 mmol) of 2-dimethylaminomethylene-1,3-bis(dimethylimmonio)propane-bis(tetrafluoroborate) and 3.86 g (34.36 mmol) of potassium tert-butylate in 70 ml of ethanol were heated under reflux for 8 h. After concentration, water and ethyl acetate were added. The organic phase was washed with a potassium hydrogensulfate solution and water, dried and evaporated. Yield: 1.87 g.

1. temperatureunder reflux for 8 h
2. concentrationAfter concentration, water and ethyl acetate
3. additionwere added
4. washThe organic phase was washed with a potassium hydrogensulfate solution and water
5. customdried
6. customevaporated