HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-[2-(4-Fluoro-phenyl)-pyrimidin-5-yl]-acrylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-(4-Fluorophenyl)pyrimidine-5-carbaldehyde | HCID 14008472 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-[2-(4-Fluoro-phenyl)-pyrimidin-5-yl]-acrylic Acid | HCID 68711909 | — |
Reaction Steps
945 mg (4.67 mmol) of 2-(4-fluoro-phenyl)-pyrimidine-5-carbaldehyde, 1544 mg (14.84 mmol) of malonic acid and 4197 mg (49.29 mmol) of piperidine in 50 ml of pyridine were stirred at 125° C. for 17 h. After concentration, water and hydrochloric acid were added, and the solid product was filtered off with suction and dried. Yield: 1.01 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304438B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-725e0039cfc64d37862b2ba614c32e8e |
| Source note | uspto-grants-2012_11 |