HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 3-[2-(4-Fluoro-phenyl)-pyrimidin-5-yl]-N-(thiazol-2-yl)-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 3-[2-(4-Fluoro-phenyl)-pyrimidin-5-yl]-acrylic Acid | HCID 68711909 | — |
| Product | 3-[2-(4-Fluoro-phenyl)-pyrimidin-5-yl]-N-(thiazol-2-yl)-acrylamide | HCID 72529226 | — |
Reaction Steps
The compound was prepared as described in Example 116(d) from 39 mg (0.16 mmol) of 3-[2-(4-fluoro-phenyl)-pyrimidin-5-yl]-acrylic acid, 32 mg (0.32 mmol) of 2-aminothiazole, 267 mg (0.68 mmol) of HATU and 65 mg (0.64 mmol) of triethylamine. Yield: 4 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304438B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-e6bbab5886904fb9ae26e5831e10e425 |
| Source note | uspto-grants-2012_11 |