HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-[2-(4-Fluoro-phenyl)-pyrimidin-5-yl]-N-(pyridin-2-yl)-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 3-[2-(4-Fluoro-phenyl)-pyrimidin-5-yl]-acrylic Acid | HCID 68711909 | — |
| Product | 3-[2-(4-Fluoro-phenyl)-pyrimidin-5-yl]-N-(pyridin-2-yl)-acrylamide | HCID 68713859 | — |
Reaction Steps
The N-substituted 3-[2-(4-fluoro-phenyl)-pyrimidin-5-yl]-acrylamides of the formula Ik, which are listed in Table 8, were prepared as described in Example 116(d) from 110 mg (0.45 mmol) of 3-[2-(4-fluoro-phenyl)-pyrimidin-5-yl]-acrylic acid, 0.9 mmol of the respective amine, 171 mg (0.45 mmol) of HATU and 136.7 mg (1.35 mmol) of triethylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304438B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-05af4055876d4e26b50c0205274bf67f |
| Source note | uspto-grants-2012_11 |