Succinimide → HCID 25116067, compound

HRID 1873776Notes

Reaction equation

HRID 1873776 reaction equation
Cl[CH2:2][C:3]([N:5]1[CH2:10][CH2:9][CH:8]([N:11]2[C:15](=[O:16])[C:14]([CH3:18])([CH3:17])[C:13]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH:26]([F:28])[F:27])=[C:21]([O:29][CH2:30][CH:31]4[CH2:33][CH2:32]4)[CH:20]=3)=[N:12]2)[CH2:7][CH2:6]1)=[O:4].[C:34]1(=[O:40])[NH:38][C:37](=[O:39])[CH2:36][CH2:35]1>>[CH:31]1([CH2:30][O:29][C:21]2[CH:20]=[C:19]([C:13]3[C:14]([CH3:17])([CH3:18])[C:15](=[O:16])[N:11]([CH:8]4[CH2:9][CH2:10][N:5]([C:3](=[O:4])[CH2:2][N:38]5[C:34](=[O:40])[CH2:35][CH2:36][C:37]5=[O:39])[CH2:6][CH2:7]4)[N:12]=3)[CH:24]=[CH:23][C:22]=2[O:25][CH:26]([F:27])[F:28])[CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 11439SuccinimideHCID 66616610HCID 66616610, compound2×

Product 1

HCID 25116067HCID 25116067, compound

Procedure

Prepared analogously as described for example 1 using 2-[1-(chloroacetyl)piperidin-4-yl]-5-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (compound A3) and succinimide as starting compounds.

Workup

  1. customPrepared analogously

Sources & evidence

ORD record
ord-8639e23fa6684930a2cc68a2d4c155cb
Source dataset
uspto-grants-2012_11
Patent number
US08304436B2

Reaction notes

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