Phthalimide → 2-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)-1H-isoindole-1,3(2H)-dione

Participants

Role	Name	HCID	Charge
Reactant	Phthalimide	HCID 6809	—
Reactant	2-[1-(chloroacetyl)piperidin-4-yl]-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one	HCID 66616609	—
Product	2-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)-1H-isoindole-1,3(2H)-dione	HCID 25058909	—

Reaction Steps

Prepared analogously as described for example 1 using 2-[1-(chloroacetyl)piperidin-4-yl]-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (compound A1) and phthalimide as starting compounds.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08304436B2
Source dataset	uspto-grants-2012_11
ORD ID	ord-aa1ec8b7e9464e939367b3cf1e7b84e5
Source note	uspto-grants-2012_11