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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1873789Generated: October 25, 2026

Chloroacetic anhydride → 2-[1-(chloroacetyl)piperidin-4-yl]-5-(3,4-dimethoxyphenyl)-4-methyl-4-propyl-2,4-dihydro-3H-pyrazol-3-one

https://huagongshe.com/reaction/1873789

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChloroacetic anhydrideHCID 10946—
Reactant5-(3,4-dimethoxyphenyl)-4-methyl-2-piperidin-4-yl-4-propyl-2,4-dihydro-3H-pyrazol-3-one hydrochlorideHCID 66616509—
Reactant2-[1-(chloroacetyl)piperidin-4-yl]-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-oneHCID 66616609—
Product2-[1-(chloroacetyl)piperidin-4-yl]-5-(3,4-dimethoxyphenyl)-4-methyl-4-propyl-2,4-dihydro-3H-pyrazol-3-oneHCID 66616736—

Reaction Steps

Prepared analogously as described for A1 using 5-(3,4-dimethoxyphenyl)-4-methyl-2-piperidin-4-yl-4-propyl-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B8) and chloroacetic anhydride as starting compounds.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08304436B2
Source datasetuspto-grants-2012_11
ORD IDord-2d086171dcb24d5d8ba746cd64c15d15
Source noteuspto-grants-2012_11