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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1873792Generated: November 1, 2026

Hydrazine hydrate (1:1) → 5-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

https://huagongshe.com/reaction/1873792

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrazine hydrate (1:1)HCID 24654—
ReactantMethyl 3-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2,2-dimethyl-3-oxopropanoateHCID 66616523—
Product5-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-oneHCID 66616429—

Reaction Steps

Prepared analogously as described for example C1 using methyl 3-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2,2-dimethyl-3-oxopropanoate (compound D3) and hydrazine hydrate as starting compounds.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08304436B2
Source datasetuspto-grants-2012_11
ORD IDord-246bb6387ebc4c2dae7d5b489e4bf4f8
Source noteuspto-grants-2012_11