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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1873798Generated: November 1, 2026

Methyl isobutyrate → Methyl 3-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2,2-dimethyl-3-oxopropanoate

https://huagongshe.com/reaction/1873798

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl isobutyrateHCID 11039—
Reactant3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl chlorideHCID 12047330—
ProductMethyl 3-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2,2-dimethyl-3-oxopropanoateHCID 66616523—

Reaction Steps

Prepared analogously as described for example D1 using methyl 2-methylproponate and 3-cyclopropylmethoxy-4-difluoromethoxybenzoyl chloride as starting compounds.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08304436B2
Source datasetuspto-grants-2012_11
ORD IDord-98e9a8a2c87f416b8fc446e18969655a
Source noteuspto-grants-2012_11