Imidazole → HCID 178455472, compound

Participants

Reaction Steps

3-Cyclobutylindazol-6-ol hydrochloride (6.45 g) which can be prepared according to the method described in Reference example 11, etc. and imidazole (5.039 g) were dissolved in DMF (100 mL; manufactured by Kanto Chemical Co., Inc.). Then, TBDPSCl (18.44 mL) was added and the mixture was stirred overnight at room temperature. To the reaction solution, water was added and extraction was carried out twice with ethyl acetate. The organic layer was washed twice with water and once with brine and dried over anhydrous sodium sulfate. After the solvent was evaporated under reduced pressure, the residue was purified by column chromatography (“COLUMN-A”; n-hexane:ethyl acetate=95:5→74:26) to obtain the title compound (9.93 g).

Provenance & Evidence