Water → HCID 135869959, compound

Participants

Reaction Steps

Tert-butyl6-(tert-butyldiphenylsilyloxy)-3-cyclobutylindazole-1-carboxylate (12.26 g) which can be prepared according to the method described in Reference example 13, etc. was dissolved in THF (83 mL; manufactured by Kanto Chemical Co., Inc.). Then, 1 mol/L-TBAF-THF solution (46 mL) was added and the mixture was stirred for 1 hour at room temperature. To the reaction solution, water and brine were added and extraction was carried out three times with ethyl acetate. The organic layer was washed with water and brine and dried over anhydrous sodium sulfate. After the solvent was evaporated under reduced pressure, the residue was purified by column chromatography (“COLUMN-B”; n-hexane:ethyl acetate=95:5→74:26) to obtain the title compound (6.4457 g).

Provenance & Evidence