HCID 20747587, compound → HCID 58091579, compound

Participants

Reaction Steps

A mixture of crude 4-acetyl-N,N-dimethylbenzamide (24.0 g) and N,N-dimethylformamide dimethyl acetal (100 mL) was heated to reflux for 15 h, cooled to room temperature and concentrated. The residue was washed with ether and dried under vacuum to provide (E)-4-(3-(dimethylamino)acryloyl)-N,N-dimethylbenzamide as brown solid (16 g, 27% yield over 2 steps). MS (ES+) m/z: 247 (M+H).

Provenance & Evidence