Dimethylamine → HCID 58091559, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the ester from Step 3 of Example 54 (39 mg, 0.084 mmol), 40% aqueous dimethylamine (1 mL, 7.90 mmol) in MeOH (0.5 mL) was attempted to heat to 220° C. under microwave, but stopped due to high pressure (>19 psi). The mixture was then heated to ˜150° C. under microwave for 1 h. Purification by reverse phase HPLC (Sunfire S10 30×250 mm column, 55 to 85% solvent B gradient) gave the expected product (47.3 mg, 70% yield). MS (ES+) m/z: 461 (M+H); LC retention time: 3.67 min (analytical HPLC Method A).

Provenance & Evidence