Morpholine → HCID 58091568, compound

Participants

Reaction Steps

Using conditions described for synthesis of Example 67, the ester from Step 3 of Example 54 was reacted with morpholine and converted Example 69. 1H NMR (400 MHz, chloroform-d) δ ppm 8.88 (1H, s), 8.10 (2H, d, J=8.31 Hz), 7.56-7.61 (1H, m), 7.48-7.56 (3H, m), 7.32 (1H, d, J=8.31 Hz), 6.38 (1H, d, J=8.31 Hz), 4.44 (1H, s), 3.82 (4H, t, J=4.78 Hz), 3.47-3.63 (4H, m), 3.19 (3H, s), 3.05 (3H, s), 1.25 (6H, s); MS (ES+) m/z: 586 (M+H); LC retention time: 3.62 min (analytical HPLC Method A).

Provenance & Evidence