Pyrrolidine → HCID 58091584, compound

Participants

Reaction Steps

Using conditions described for synthesis of Example 67, the acid from Step 4 of Example 54 was reacted with pyrrolidine and converted Example 70. 1H NMR (400 MHz, chloroform-d) δ ppm 8.90 (1H, s), 8.06 (2H, d, J=8.31 Hz), 7.56 (2H, s), 7.51 (2H, d, J=8.31 Hz), 7.42 (1H, d, J=8.81 Hz), 6.27 (1H, d, J=8.56 Hz), 4.43 (1H, s), 3.53-3.64 (4H, m), 3.19 (3H, s), 3.06 (3H, s), 2.00-2.16 (4H, m), 1.25 (3H, s), 1.23 (3H, s); MS (ES+) m/z: 570 (M+H); LC retention time: 3.88 min (analytical HPLC Method A).

Provenance & Evidence