N-(7-Oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide → HCID 178474409, compound

HRID 1874067Notes

Reaction equation

HRID 1874067 reaction equation
[O:1]=[C:2]1[C:10]2[S:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[N:7][C:6]=2[CH2:5][CH2:4][CH2:3]1.[F:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][N:17]=1>>[F:15][C:16]1[N:17]=[CH:18][C:19]([C:20]([C:3]2[CH2:4][CH2:5][C:6]3[N:7]=[C:8]([NH:11][C:12](=[O:14])[CH3:13])[S:9][C:10]=3[C:2]=2[OH:1])=[O:21])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 597793N-(7-Oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamideHCID 146236022-Fluoropyridine-5-carbonyl chloride

Product 1

HCID 178474409HCID 178474409, compound

Procedure

The title compound is synthesized according to general procedure A1 starting form 21.0 g (100 mmol), N-(7-oxo-4,5,6,7-tetrahydro-benzothiazol-2-yl)-acetamide and 20.2 g (120 mmol, 95% pure) 6-fluoro nicotinic acid chloride. Yield: 27.0 g.

Sources & evidence

ORD record
ord-d6b4641c9dfd49bfa313219e83da547a
Source dataset
uspto-grants-2012_11
Patent number
US08304556B2

Reaction notes

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