Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Reactant | 4-Bromo-2-fluorophenol | HCID 2724981 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 11722548 | HCID 11722548 | — |
Reaction Steps
4-Bromo-2-fluorophenol (16.7 g, 87.4 mmol) is dissolved in 100 mL DMF. N-(2-Chloro-ethyl)morpholine hydrochloride (18.5 g, 99.4 mmol), potassium carbonate (28.0 g, 203 mmol) and potassium iodide (100 mg, 0.602 mmol) are added and the reaction mixture is stirred for 3 h at 65° C. The reaction mixture is poured in water and extracted with ethyl acetate. The combined organic phases are washed with water and brine, dried over magnesium sulfate and concentrated in vacuo. Yield: 27.7 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08304556B2 |
|---|
| Source dataset | uspto-grants-2012_11 |
|---|
| ORD ID | ord-ba9bebfdaffe473092afae5018c9c99e |
|---|
| Source note | uspto-grants-2012_11 |
|---|
