tert-Butyl carbazate → HCID 67159318, compound

HRID 1874088Notes

Reaction equation

HRID 1874088 reaction equation
O.[ClH:2].[NH:3]1[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1.[C:10]([O:14][C:15](=[O:18])[NH:16][NH2:17])([CH3:13])([CH3:12])[CH3:11]>CO>[ClH:2].[C:10]([O:14][C:15]([NH:16][N:17]=[C:6]1[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]1)=[O:18])([CH3:13])([CH3:12])[CH3:11]

Participants

4

Reactant 2

HCID 70091tert-Butyl carbazateHCID 2723901Piperonylamine

Product 1

HCID 67159318HCID 67159318, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4-piperidone hydrochloride monohydrate (31.2 g, 203 mmol) and tert-butylcarbazate (26.8 g, 203 mmol) in 100 mL MeOH is stirred over weekend at RT and then concentrated in vacuo. The residue is crystallized from ethyl acetate. Yield: 47.5 g.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe residue is crystallized from ethyl acetate

Sources & evidence

ORD record
ord-a8f8409ae6c64534a8137e32551c26ba
Source dataset
uspto-grants-2012_11
Patent number
US08304556B2

Reaction notes

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