HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(Dimethylamino)-1-[4-(phenylmethoxy)phenyl]ethyl]cyclohexanol → Desvenlafaxine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(Dimethylamino)-1-[4-(phenylmethoxy)phenyl]ethyl]cyclohexanol | HCID 20129923 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Desvenlafaxine | HCID 125017 | 81.08% |
Reaction Steps
1-[2-(Dimethylamino)-1-(4-benzyloxyphenyl)ethyl]cyclohexanol (30 g) was dissolved in methanol (600 ml), charged with 10% palladium on carbon (3 g) and hydrogenated pressure for 6 h at room temperature. The catalyst was filtered, washed with methanol, and combined filtrate evaporated under reduced pressure to give 18 g (81.08%) of the 1-[2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304578B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-03b2eb875dc24d14894102cbef2bda7f |
| Source note | uspto-grants-2012_11 |