HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoacetamide → HCID 68991696, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoacetamide | HCID 3727 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 57749374 | HCID 57749374 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68991696 | HCID 68991696 | 75.4% |
Reaction Steps
In the same manner as in Reference Example 5 and using N-{2-chloro-5-[(6-{[(4-methylphenyl)sulfonyl]amino}pyridin-3-yl)oxy]phenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide (364 mg, 0.711 mmol), N,N-diisopropylethylamine (161 μl, 0.924 mmol), iodoacetamide (171 mg, 0.924 mmol) and N,N-dimethylformamide (5 mL) as starting materials, the title compound (305 mg, 75%) was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304557B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-b1eaaa526f8b4a6b8f8ef1b342a50ff9 |
| Source note | uspto-grants-2012_11 |