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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1874329Generated: November 2, 2026

Iodoacetamide → HCID 68991696, compound

https://huagongshe.com/reaction/1874329

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIodoacetamideHCID 3727—
ReactantDiisopropylethylamineHCID 81531—
ReactantHCID 57749374HCID 57749374—
SolventDimethylformamideHCID 6228—
ProductHCID 68991696HCID 6899169675.4%

Reaction Steps

In the same manner as in Reference Example 5 and using N-{2-chloro-5-[(6-{[(4-methylphenyl)sulfonyl]amino}pyridin-3-yl)oxy]phenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide (364 mg, 0.711 mmol), N,N-diisopropylethylamine (161 μl, 0.924 mmol), iodoacetamide (171 mg, 0.924 mmol) and N,N-dimethylformamide (5 mL) as starting materials, the title compound (305 mg, 75%) was obtained as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08304557B2
Source datasetuspto-grants-2012_11
ORD IDord-b1eaaa526f8b4a6b8f8ef1b342a50ff9
Source noteuspto-grants-2012_11