4-Toluenesulfonyl chloride → 1,3-dimethyl-N-{2-methyl-5-[(6-{[(4-methylphenyl)sulfonyl]amino}pyridin-3-yl)oxy]phenyl}-1H-pyrazole-5-carboxamide

Participants

Reaction Steps

In the same manner as in Reference Example 4 and using N-{5-[(6-aminopyridin-3-yl)oxy]-2-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide (2.61 g, 7.75 mmol), p-toluenesulfonyl chloride (1.77 g, 9.31 mmol) and pyridine (15 mL) as starting materials, the title compound (2.92 g, 77%) was obtained as a white solid.

Provenance & Evidence