HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → Tert-butyl 3-(6-nitropyridin-3-yloxy)phenylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | tert-butyl N-(3-hydroxyphenyl)carbamate | HCID 312485 | — |
| Reactant | 5-Bromo-2-nitropyridine | HCID 817620 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Tert-butyl 3-(6-nitropyridin-3-yloxy)phenylcarbamate | HCID 57749209 | 66.1% |
Reaction Steps
In the same manner as in Reference Example 33 and using tert-butyl (3-hydroxyphenyl)carbamate (18.9 g, 90.3 mmol), 5-bromo-2-nitropyridine (15.3 g, 75.3 mmol), cesium carbonate (36.9 g, 113 mmol) and N,N-dimethylformamide (150 mL) as starting materials, the title compound (16.5 g, 66%) was obtained as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304557B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-9076c05ac0334cb590fecdb3047852eb |
| Source note | uspto-grants-2012_11 |