HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(3-hydroxyphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Aminophenol | HCID 11568 | — |
| Reactant | 2,5-Dimethyl-2H-pyrazole-3-carbonyl chloride | HCID 2736299 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(3-hydroxyphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide | HCID 19481482 | 90% |
Reaction Steps
In the same manner as in Reference Example 11 and using 3-aminophenol (2.11 g, 19.3 mmol), triethylamine (2.81 mL, 20.3 mmol), 1,3-dimethyl-1H-pyrazole-5-carbonyl chloride (3.07 g, 19.4 mmol) and tetrahydrofuran (30 mL) as starting materials, the title compound (4.00 g, 90%) was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304557B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-e5a3316baa474928906f4985f5c44ec6 |
| Source note | uspto-grants-2012_11 |