反应详情

温度

80 °C

To a mixture of rhodium acetate (100 mg) and propionitrile (15 mL) was added ethyl 2-diazo-4,4,4-trifluoro-3-oxobutanoate (4.20 g, 20.0 mmol) over 12 hr, and the mixture was stirred at 80° C. for 5 days. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (hexane/ethyl acetate=90/10→0/100) to give the title compound (2.03 g, 43%) as a yellow oil.

1. filtrationThe reaction mixture was filtered through celite
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue was purified by column chromatography (hexane/ethyl acetate=90/10→0/100)