Tetrahydrofuran → N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)phenyl]-1,4-dimethyl-1H-pyrrole-3-carboxamide

Participants

Reaction Steps

In the same manner as in Example 18-4 and using 1,4-dimethyl-1H-pyrrole-3-carboxylic acid (270 mg, 1.94 mmol), tetrahydrofuran (7 mL), oxalyl chloride (203 μL, 2.32 mmol), N-[6-(3-aminophenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (200 mg, 0.646 mmol), N,N-dimethylformamide (1 drop) and N,N-dimethylacetamide (3 mL) as starting materials, the title compound (79.2 mg, 28%) was obtained as a white solid.

Provenance & Evidence